Sources
Everything VarInsight shows comes from one of these. Nothing is derived, inferred or generated. Where a source is reached through another, that is stated.
Variant identity, ClinVar assertions, gnomAD allele frequency
Aggregates each upstream under that upstream’s own licence.
Queried with an explicit assembly parameter on every request, because its default is GRCh37.
Clinical significance assertions, via MyVariant.info
Public domain, as US government work.
Every assertion links to its own RCV submission record, not just to the variant page.
Gene constraint (pLI, LOEUF, missense z) and allele frequency linkouts
Data released under CC0 by the Broad Institute.
Constraint is read from the gnomAD v4 GraphQL API. MyVariant.info carries no gene-level constraint.
Literature
Metadata reusable under the terms Europe PMC publishes.
Searched by gene combined with a quoted group of variant aliases, sorted by citations.
Resolving notations this tool cannot parse — Ensembl transcript and LRG HGVS
Ensembl data is released without restriction; see their disclaimer.
Called only when local parsing fails, and split across two hosts by assembly. It returns a versioned RefSeq accession, which pins the build and is checked before use.
Attribution
VarInsight is not affiliated with, endorsed by, or connected to NCBI, EMBL-EBI, the Broad Institute or the Scripps Research Institute. Their names appear here to identify whose data is being shown, which is the point of showing them.